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Case Report: Diagnostic challenges in differentiated-type vulvar intraepithelial neoplasia
Jifeng Peng1, Yanyan Li2, Xiaoling Sun1
1School of Nursing and Health, Xi'an Innovation College of Yan'an University, Xi'an, Shaanxi, China.
Frontiers in Oncology
|December 3, 2025
Summary
Differentiated vulvar intraepithelial neoplasia (dVIN), an HPV-independent lesion, can progress to squamous cell carcinoma and metastasize. Early detection through vigilant assessment and immunohistochemistry is crucial for better outcomes in older women.
Area of Science:
- Gynecologic Pathology
- Oncology
- Dermatopathology
Background:
- Differentiated-type vulvar intraepithelial neoplasia (dVIN) is an HPV-independent precursor lesion.
- dVIN is associated with keratinizing squamous cell carcinoma and aberrant p53/p16 immunophenotypes.
- It carries a higher risk of progression and predominantly affects older women.
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