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Mesoporous Silica Microparticle Tablets for Optimised Formulation and Overcoming Compressibility Challenges.

Mohamad Anas Al Tahan1,2, Craig Russell1, Ali Al-Khattawi1

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Summary
This summary is machine-generated.

Formulating oral tablets with SYLOID XDP 3150 (SYLOID) mesoporous silica microparticles is challenging due to poor compressibility. Excipient support is crucial to overcome SYLOID

Keywords:
SYLOIDmesoporous silicamicroparticlesporositytablets

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tablets are a common dosage form, but incorporating mesoporous silica microparticles like SYLOID XDP 3150 (SYLOID) for enhanced drug release presents formulation challenges.
  • Poor compressibility and disintegration characteristics of SYLOID hinder its use in direct compression tablet manufacturing.

Purpose of the Study:

  • To explore dynamic formulation strategies for successful incorporation of SYLOID into oral tablet formulations.
  • To evaluate the impact of varying microcrystalline cellulose (MCC) and lactose monohydrate ratios on tablet properties when SYLOID is included.

Main Methods:

  • Tablets were prepared via direct compression using different ratios of Avicel PH 102 (MCC) and lactose monohydrate (25:75, 50:50, 75:25) with SYLOID at 0%, 20%, and 40% (w/w).
  • Tablet properties including porosity, tensile strength, friability, and disintegration time were assessed. SYLOID alone was compressed to determine baseline behavior.

Main Results:

  • Direct compression of SYLOID alone failed due to poor compactability and fragmentation.
  • Increased Avicel content improved tablet strength and reduced porosity, while higher SYLOID levels increased porosity but decreased mechanical integrity.
  • Lactose-rich formulations exhibited faster disintegration, whereas increased SYLOID content delayed it due to hydrophobicity.

Conclusions:

  • SYLOID significantly impacts tablet architecture and performance, requiring excipient support (superdisintegrant and binder) to meet pharmacopeial standards.
  • Successful formulation of SYLOID-containing tablets necessitates careful selection of excipients to mitigate its inherent limitations.
  • Further research on drug-loaded SYLOID tablets is warranted to investigate their effect on drug release and oral bioavailability.