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Related Experiment Video

Updated: May 2, 2026

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Comparing Lower- and Higher-Order Aberrations: Zywave® II Hartmann-Shack Wavefront Aberrometer versus Peramis

Siamak Zarei-Ghanavati1,2, Mojtaba Abrishami1,3, Maryam Hedayati1

  • 1Eye Research Center, Department of Ophthalmology, Khatam-Al-Anbia Eye Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of Current Ophthalmology
|December 3, 2025
PubMed
Summary
This summary is machine-generated.

The Zywave II and Peramis aberrometers show good agreement for lower-order aberrations (LOA) and total higher-order aberrations (HOA). However, they exhibit poor agreement for specific third- and fourth-order aberrations, indicating these measurements are not interchangeable.

Keywords:
AberrometerHartmann–Shake technologyHigher-order aberrationPeramis CSO aberrometerPyramidal technologyZywave® II wavefront aberrometer

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Area of Science:

  • Ophthalmology
  • Optometry
  • Vision Science

Background:

  • Ocular aberration measurement is crucial for understanding visual quality.
  • Aberrometers like Zywave II and Peramis are used to quantify lower- and higher-order aberrations (LOA and HOA).
  • Assessing device agreement is essential for reliable clinical application.

Purpose of the Study:

  • To evaluate the agreement between Zywave II and Peramis aberrometers for LOA and HOA measurements.
  • To compare dynamic aberration measurements without cycloplegia.

Main Methods:

  • Prospective comparative study of 42 eyes from 21 participants (20-45 years).
  • Exclusion of participants with ocular surgery, trauma, recent contact lens wear, or ocular/systemic diseases.
  • Comparison of LOA (sphere, cylinder) and RMS of coma, spherical aberration, and total third- and fourth-order HOAs between devices.

Main Results:

  • Excellent agreement for LOAs (sphere, cylinder) with ICCs of 0.96 (right eye) and 0.95 (left eye) at a 6 mm pupil.
  • Good-to-excellent agreement for total HOA (t.HOA) and total aberration RMS at 5 mm and 6 mm pupil sizes.
  • Poor agreement was found for third- and fourth-order aberrations at both pupil sizes.

Conclusions:

  • Zywave II and Peramis aberrometers demonstrate agreement in measuring sphere, cylinder, t.HOA, and total aberration.
  • Significant differences in third- and fourth-order aberration measurements indicate non-interchangeability between the devices.
  • Clinical use requires caution when interpreting specific higher-order aberration data from these aberrometers.