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Updated: Jan 9, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing.

Yusheng Zhu^1,2, Jarrett Sell³

¹Department of Pathology and Laboratory Medicine, Penn State University College of Medicine, Hershey, PA, United States.

Clinical Chemistry

|December 3, 2025

Summary

This summary is machine-generated.

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) uses antiviral medications to prevent HIV. New long-acting injectables and improved HIV testing, including self-testing, enhance PrEP effectiveness and accessibility for HIV prevention.

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Area of Science:

Infectious Diseases
Public Health
Pharmacology

Background:

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) involves antiviral medications to prevent HIV acquisition in at-risk individuals.
Current oral PrEP medications face adherence challenges, prompting the development of long-acting injectable alternatives.
Regular HIV testing is crucial for initiating, restarting, and maintaining PrEP therapy.

Purpose of the Study:

To review current practices and recent advancements in HIV pre-exposure prophylaxis (PrEP).
To highlight the role of evolving medication and testing technologies in enhancing PrEP effectiveness.
To discuss strategies for improving PrEP accessibility and uptake.

Main Methods:

Review of current literature on HIV PrEP medications and testing strategies.
Analysis of adherence challenges associated with oral PrEP.
Evaluation of emerging long-acting injectable PrEP options and novel HIV testing methods.

Main Results:

Long-acting injectable PrEP medications show promise for improving adherence compared to daily oral regimens.
Various HIV testing methods are employed, including laboratory assays, rapid tests, and increasingly, HIV self-testing (HIVST).
Provider-administered testing can be a barrier to PrEP uptake, underscoring the importance of accessible self-testing options.

Conclusions:

HIV PrEP and associated monitoring are fundamental components of comprehensive HIV prevention strategies.
Advancements in PrEP medications, such as novel long-acting agents and broadly neutralizing antibodies, are needed to further improve efficacy.
Enhanced accessibility of PrEP services and the development of high-sensitivity HIV tests, particularly nucleic acid-based HIVST, are critical for optimizing HIV prevention outcomes.