In silico Approach to Investigate Magnetoelectric Nanoparticle Effects for minimally-invasive Brain Stimulation

This study presents a computational framework for investigating magnetoelectric nanoparticles (MENPs) as a tool for minimally-invasive neuromodulation. Through in-silico modeling, we analyze both single-particle behavior and their collective effects in neural tissue. Our results demonstrate that MENPs at 0.1% w/v concentration in brain tissue generate electric fields sufficient for neural modulation, providing quantitative insights to guide experimental studies exploring MENPs for targeted brain stimulation.Clinical Relevance- This computational approach supports the development of minimally-invasive, targeted neuromodulation techniques using magnetoelectric nanoparticles, offering potential therapeutic applications without the risks associated with invasive electrode implantation.