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Related Experiment Video

Updated: Jan 9, 2026

Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
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Dose-Dependent Regional Synchronicity Changes Using Weighted Phase Lag Index: Towards Optimizing Vagus Nerve

Paloma Carcamo Cerda, Pablo Aqueveque, Antoine Nonclercq

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    Summary

    Vagus nerve stimulation (VNS) for drug-resistant epilepsy shows varied responses. Non-responders displayed increased brain synchrony with higher VNS intensity, suggesting personalized therapy approaches are needed.

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    Area of Science:

    • Neuroscience
    • Epilepsy Research
    • Brain-Computer Interfaces

    Background:

    • Vagus nerve stimulation (VNS) is a recognized treatment for drug-resistant epilepsy (DRE).
    • Individual patient responses to VNS therapy for DRE vary significantly.
    • Understanding the neural mechanisms underlying VNS efficacy is crucial for treatment optimization.

    Purpose of the Study:

    • To investigate the dose-dependent effects of VNS on regional brain synchronization at an individual level.
    • To analyze brain connectivity patterns using the weighted Phase Lag Index (wPLI) across different frequency bands.
    • To differentiate neural responses to VNS between responders and non-responders in DRE patients.

    Main Methods:

    • Collected EEG data from four DRE patients (two responders, two non-responders).
    • Applied controlled VNS intensities and analyzed brain synchronization using wPLI across multiple frequency bands.
    • Examined dose-dependent changes in brain synchrony in relation to VNS intensity.

    Main Results:

    • Non-responders showed increased brain synchrony at higher VNS intensity levels.
    • Elevated synchrony in non-responders was particularly noted in the beta frequency band and broadband.
    • Individualized EEG analysis revealed distinct neural responses to VNS intensity.

    Conclusions:

    • Brain synchronization patterns during VNS are individualized in DRE patients.
    • Increased synchrony in non-responders at higher VNS intensities may indicate a need for tailored stimulation parameters.
    • Dose-dependent connectivity analysis offers a pathway for personalized VNS titration strategies to improve DRE treatment outcomes.