Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of blood-flow velocity and direction on coagulation zone symmetry induced by microwave ablation using ECO antenna.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2026
Same author

A Compact Computational Model for Hyperthermia-Controlled Drug Release Based on Krogh-Cylinder Approach.

International journal for numerical methods in biomedical engineering·2026
Same author

Staying Despite the Intention to Leave: Insights from Frontline Nurses and Nurse Managers from a Qualitative Descriptive Study.

Nursing reports (Pavia, Italy)·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Multi-objective optimization framework to plan laser ablation procedure for prostate tumors through a genetic algorithm.

Computer methods and programs in biomedicine·2025
Same author

Is a No-Restraint Policy Associated with Increased Aggression Towards Healthcare Professionals Among Inpatient Psychiatric Units? A 16-Year Retrospective Observational Study Conducted in Italy.

Nursing reports (Pavia, Italy)·2024

Related Experiment Video

Updated: Jan 9, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

1.4K

Optimizing Hyperthermia-Mediated Drug Delivery for Hepatocellular Carcinoma: A Multi-Objective Genetic Algorithm

Gabriele Adabbo, Assunta Andreozzi, Marcello Iasiello

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |December 3, 2025
    PubMed
    Summary

    This study optimizes hyperthermia-mediated drug delivery using thermo-sensitive liposomes (TSLs) for liver cancer (HCC). A computational method enhances treatment efficacy by maximizing tumor cell kill while minimizing tissue damage.

    More Related Videos

    Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids
    07:25

    Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

    Published on: August 18, 2023

    2.4K
    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
    06:38

    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

    Published on: September 12, 2019

    9.4K

    Related Experiment Videos

    Last Updated: Jan 9, 2026

    Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
    09:23

    Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

    Published on: October 10, 2025

    1.4K
    Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids
    07:25

    Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

    Published on: August 18, 2023

    2.4K
    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
    06:38

    An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

    Published on: September 12, 2019

    9.4K

    Area of Science:

    • Biomedical Engineering
    • Computational Biology
    • Oncology

    Background:

    • Hepatocellular carcinoma (HCC) presents treatment challenges.
    • Hyperthermia-mediated drug delivery using thermo-sensitive liposomes (TSLs) offers a promising therapeutic strategy.
    • Optimizing TSLs for HCC requires balancing heating protocols and drug release.

    Purpose of the Study:

    • To optimize hyperthermia-mediated drug delivery for hepatocellular carcinoma (HCC) using thermo-sensitive liposomes (TSLs).
    • To develop a computational method for maximizing tumor cell kill rates.
    • To minimize thermal damage to surrounding tissues during treatment.

    Main Methods:

    • Utilized a Multi-Objective Genetic Algorithm (MOGA) for optimization.
    • Integrated Pennes' bioheat and drug diffusion equations into finite element simulations.
    • Balanced critical parameters governing heating protocols and drug release.

    Main Results:

    • Achieved optimized input protocols for TSL-mediated hyperthermia in HCC.
    • Demonstrated improved therapeutic outcomes through computational modeling.
    • Identified a pathway for enhanced drug delivery and reduced side effects.

    Conclusions:

    • The study presents a novel computational approach for optimizing TSL-based hyperthermia for HCC.
    • This method offers a more targeted and efficient treatment alternative.
    • The findings have significant clinical relevance for improving HCC patient outcomes.