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Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

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Published on: December 1, 2023

A Compact Computational Model for Hyperthermia-Controlled Drug Release Based on Krogh-Cylinder Approach.

Gabriele Adabbo¹, Alberto Coccarelli^2,3, Marcello Iasiello⁴

¹Dipartimento di Medicina e Scienze Della Salute "Vincenzo Tiberio", Università del Molise, Campobasso, Italy.

International Journal for Numerical Methods in Biomedical Engineering

|May 4, 2026

Summary

Hyperthermia enhances chemotherapy by using temperature-sensitive liposomes (TSLs) for targeted drug delivery. A new model shows preheating tumors improves drug concentration by 29.4% with minimal risk of tissue damage.

Keywords:

1D modeling Krogh cylinder model hyperthermia‐mediated drug delivery thermosensitive liposomes

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Published on: December 13, 2015

Area of Science:

Biomedical Engineering
Computational Biology
Pharmacology

Background:

Hyperthermia-mediated drug delivery enhances chemotherapy efficacy and reduces toxicity.
Thermosensitive liposomes (TSLs) release drugs at elevated temperatures for targeted tumor treatment.

Purpose of the Study:

To develop and validate a hybrid multiscale model for simulating TSL transport and drug release in tumors.
To investigate the impact of hyperthermia on drug delivery and optimize treatment strategies.

Main Methods:

A hybrid multiscale model combining Krogh cylinder, 1D transport equations, and 0D kinetics.
Incorporation of physiological processes: blood flow, diffusion, cellular uptake, and Pennes' bioheat equation.
Temperature-dependent functions for physiological parameters and sensitivity analysis.

Main Results:

Microvascular permeability, tissue diffusivity, and Krogh cylinder radius are key parameters influencing drug delivery.
A 30-min preheating phase increased internalized doxorubicin by 29.4% with only 5% necrosis probability.
The model is computationally efficient and physiologically detailed.

Conclusions:

The developed model effectively simulates hyperthermia-assisted chemotherapy using TSLs.
Preheating is a viable strategy to significantly enhance drug delivery and treatment efficacy.
The model is suitable for treatment planning and real-time therapeutic decision-making in solid tumors.