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Ultra-flexible Coil for Wireless Endovascular Cortical Stimulation.

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    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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    Researchers developed a flexible, wireless endovascular neural stimulator for minimally invasive brain stimulation. This device offers a safer alternative to surgery for treating neurological disorders.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Medical Devices

    Background:

    • Endovascular devices offer minimally invasive options for neural stimulation in treating neurological disorders.
    • Existing wired endovascular devices face challenges like endothelial cell response and wire wear.
    • Open-skull surgeries carry significant risks, necessitating advanced alternatives.

    Purpose of the Study:

    • To develop and validate a fully wireless, ultra-flexible endovascular neural stimulator.
    • To assess the feasibility of using this device for cortical neural stimulation.
    • To demonstrate a safer, minimally invasive alternative for treating neurological conditions.

    Main Methods:

    • Designed a novel coil on a mesh structure for ultra-flexibility.
    • Implanted the device into the superior sagittal sinus of a sheep model using catheter-based procedures.
    • Analyzed wireless power transfer efficiency (PTE) theoretically, via simulation, and through benchtop and animal experiments.
    • Validated neural stimulation using external pulse-modulation.

    Main Results:

    • Successfully implanted the flexible device into cerebral veins, showing adaptability to complex vasculature.
    • Demonstrated efficient wireless power transfer and validated neural stimulation capabilities.
    • Confirmed the device's compatibility with standard neurovascular catheter procedures.

    Conclusions:

    • The wireless endovascular neural stimulator is feasible for minimally invasive cortical neural stimulation.
    • This technology avoids risks associated with open-skull surgery and wired devices.
    • Presents a promising solution for future flexible neural interfaces and treatment of neurological disorders like paralysis and epilepsy.