Development of a Demonstrator for the Excitation of Magneto-Electric Nano Particles in Biomedical Treatments...

Recent advancements in the field of tumor innervation have revealed that neural activity within the tumor microenvironment plays a significant role in cancer progression. The modulation of neural signals in that area offers a promising therapeutic approach for controlling cancer growth. A particularly innovative technique, currently in approbation for deep brain stimulation (DBS), involves the use of magneto electric nanoparticles (MENPs) for wireless, injectable neuromodulation. This technique could potentially enable application on several biomedical treatments involving neural connectivity. This would include neurodegenerative diseases, tumors or motor dysfunctions in all parts of the body.This study focuses on the design of a device capable of generating a magnetic field suitable to activate MENPs for further research in biomedical treatment therapy. The device incorporates a Helmholtz coil and neodymium magnets to produce both an AC magnetic field of 0.7 mT A^-1 and a DC magnetic bias field of 160 mT to 230 mT. Simulations of the DC magnetic bias field and quantitative and qualitative AC magnetic field measurements show promising alignment with experimental results.These findings lay the groundwork for future exploration of MENP-based neuromodulation, offering a platform for advancing numerous biomedical treatments that involve neural connectivity.