Editorial: Early Metabolic Drivers of Neurodevelopmental Disorders: Potential Pathways to Early Detection and Novel
1Autism Discovery and Treatment Foundation, Phoenix, Arizona.
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The origins of neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) remain complex and incompletely understood. ASD, for instance, is paradoxically both highly heritable and strongly associated with de novo (ie, non-inherited) genetic mutations, with hundreds of genes implicated to date. This pattern suggests that broader, system-level mechanisms may contribute to the pathophysiology of NDDs and their heritability.1 Emerging evidence indicates that disruptions in critical cellular biochemical pathways may represent shared biological foundations across these disorders.2.
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