Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

1,25(OH)<sub>2</sub>D<sub>3</sub> up-regulated mitochondrial dynamics and biogenesis to modulate steroidogenesis in the scent glands of muskrats (Ondatra zibethicus).

The Journal of steroid biochemistry and molecular biology·2025

Same author

Prognostic Nutritional Index Trajectories Predict Kidney Function in Kidney Transplant Recipients: A Latent Class Growth Model Study.

Annals of transplantation·2025

Same author

The actual performance of large language models in providing liver cirrhosis-related information: A comparative study.

International journal of medical informatics·2025

Same author

Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis.

Burns : journal of the International Society for Burn Injuries·2025

Same author

A review shows that ATG10 has been identified as a potential prognostic marker and therapeutic target for cancer patients based on real-world studies.

Frontiers in oncology·2025

Same author

Deciphering of electron transfer and microbial community of electrogenic oxygen reducing biofilms to sulfamethoxazole stress.

Bioresource technology·2025

Same journal

Energy intake and nutritional status in older adults undergoing long-term rehabilitation for chronic diseases: A multicentre prospective study.

Asia Pacific journal of clinical nutrition·2026

Same journal

Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.

Asia Pacific journal of clinical nutrition·2026

Same journal

Association between ultra-processed food exposure and gestational diabetes mellitus by diet balance index for pregnancy in Chinese women.

Asia Pacific journal of clinical nutrition·2026

Same journal

The association between family economic status and nutrient intake among preschool children attending nursery schools in Japan.

Asia Pacific journal of clinical nutrition·2026

Same journal

Malnutrition and associated geriatric syndromes in older outpatients: A comprehensive analysis.

Asia Pacific journal of clinical nutrition·2026

Same journal

Concordance evaluation of a nutrition self-assessment app and clinical experts in estimating energy requirements and deficits among ONS consumers.

Asia Pacific journal of clinical nutrition·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization

Shaodong Chang¹, Ke Shi², Minheng Zhang³

¹Department of Intensive Care Unit, Shanxi Zezhou County People's Hospital, Jincheng, Shanxi Province, China.

Asia Pacific Journal of Clinical Nutrition

|December 3, 2025

Summary

This summary is machine-generated.

This study found that a higher intake of oily fish may reduce the risk of developing multiple sclerosis (MS). This dietary habit was linked to lower MS susceptibility in individuals of European ancestry.

Keywords:

Mendelian randomization dietary habits genome-wide association studies inverse variance weighted multiple sclerosis

More Related Videos

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jan 9, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

Area of Science:

Neuroepidemiology
Nutritional Science
Genetic Epidemiology

Background:

Observational studies suggest a link between diet and multiple sclerosis (MS) occurrence.
Few Mendelian randomization (MR) studies have investigated this association.
Understanding dietary impacts on MS is crucial for public health.

Purpose of the Study:

To investigate potential causal relationships between 21 dietary habits and MS risk.
To utilize Mendelian randomization (MR) analysis for robust causal inference.
To examine dietary influences on MS susceptibility in European populations.

Main Methods:

A two-sample MR study design was employed.
Genome-wide association study (GWAS) data from the IEU Open GWAS project were utilized.
Sensitivity analyses including MR-Egger and Cochran's Q tests were performed to assess pleiotropy and heterogeneity.

Main Results:

A significant inverse association was found between genetically predicted oily fish intake and MS risk (OR: 0.557, p=0.013).
Sensitivity analyses confirmed the robustness of this finding.
No significant associations were observed for other dietary habits and MS risk.

Conclusions:

This MR analysis provides evidence for an association between dietary patterns and MS risk.
Higher consumption of oily fish is associated with a reduced risk of developing MS.
Findings highlight the potential role of specific dietary factors in MS prevention.