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Long-Term All-Cause Mortality After Acute Pancreatitis: Median 7-Year Follow-Up
Elmas Biberci Keskin1, Bahadır Taşlıdere2, Sercan Kiremitçi2
1Department of Internal Medicine, Health Sciences University, Hamidiye Etfal Education and Research Hospital, İstanbul, Türkiye.
Summary
This study investigated long-term mortality after acute pancreatitis. Age, diabetes, and complications impact survival, with alcoholic pancreatitis showing the worst long-term prognosis.
Area of Science:
- Gastroenterology and Hepatology
- Public Health
- Epidemiology
Background:
- Acute pancreatitis is a severe condition with high in-hospital mortality, especially with complications.
- Limited data exists on the long-term all-cause mortality following acute pancreatitis and its etiological associations.
Purpose of the Study:
- To determine both short- and very long-term all-cause mortality rates in patients with acute pancreatitis.
- To identify predictors of long-term mortality and analyze the impact of etiology on survival.
Main Methods:
- Retrospective analysis of 689 patients admitted with acute pancreatitis between 2012 and 2023.
- Data collection included demographics and laboratory values; all-cause mortality was tracked via a national death notification system.
Main Results:
- The median follow-up was 86 months. Overall in-hospital mortality was 2.8%, and 1-year all-cause mortality was 5.4%.
- Independent predictors for long-term mortality included age, diabetes mellitus, and in-hospital complications.
- Alcoholic and hypertriglyceridemia-induced pancreatitis had higher in-hospital mortality, but alcoholic pancreatitis showed the worst long-term prognosis.
Conclusions:
- Age, diabetes, and in-hospital complications significantly influence long-term survival after acute pancreatitis.
- Alcoholic pancreatitis, despite underrepresentation, presents the highest long-term all-cause mortality, warranting further investigation.
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