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Uncertainty: Confidence Intervals00:54

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The confidence interval is the range of values around the mean that contains the true mean. It is expressed as a probability percentage. The interpretation of a 95% confidence interval, for instance, is that the statistician is 95% confident that the true mean falls within the interval. The upper and lower limits of this range are known as confidence limits. The confidence limits for the true mean are estimated from the sample's mean, the standard deviation, and the statistical factor...
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Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
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An experiment often consists of more than a single step. In this case, measurements at each step give rise to uncertainty. Because the measurements occur in successive steps, the uncertainty in one step necessarily contributes to that in the subsequent step. As we perform statistical analysis on these types of experiments, we must learn to account for the propagation of uncertainty from one step to the next. The propagation of uncertainty depends on the type of arithmetic operation performed on...
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The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
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Lasso Monte Carlo, a variation on multi fidelity methods for high-dimensional uncertainty quantification.

Arnau Albà1,2, Romana Boiger1, Dimitri Rochman1

  • 1Paul Scherrer Institut, Villigen, Switzerland.

Journal of Applied Statistics
|December 4, 2025
PubMed
Summary

Lasso Monte Carlo (LMC) offers efficient uncertainty quantification (UQ) for high-dimensional problems. This new method reduces computational costs significantly compared to traditional Monte Carlo methods.

Keywords:
62-0862J0762J1062P35Multifidelity Monte Carlocurse of dimensionalitylassouncertainty quantification

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Area of Science:

  • Computational Science and Engineering
  • Statistical Modeling

Background:

  • Uncertainty quantification (UQ) is crucial across science and engineering.
  • Common UQ methods include Monte Carlo (slow convergence) and surrogate modeling (curse of dimensionality for high-dimensional problems).

Purpose of the Study:

  • To introduce Lasso Monte Carlo (LMC), a novel technique for efficient UQ in high-dimensional settings.
  • To reduce the computational cost of UQ while maintaining accuracy.

Main Methods:

  • Combines a Lasso surrogate model with multifidelity Monte Carlo techniques.
  • Develops mathematical guarantees for the unbiasedness of the LMC method.

Main Results:

  • LMC demonstrates higher accuracy than simple Monte Carlo and other multifidelity methods in benchmark tests.
  • Achieves computational cost reductions of over 5x compared to simple Monte Carlo.
  • Validated on toy problems and a nuclear engineering UQ application.

Conclusions:

  • Lasso Monte Carlo (LMC) provides a computationally efficient and accurate approach for UQ in high-dimensional problems.
  • LMC overcomes the limitations of traditional methods, making UQ more feasible for complex applications.