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Related Concept Videos

Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Related Experiment Video

Updated: May 2, 2026

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
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Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and

Jacob A Andrews1,2, Michael P Craven1,3, Boliang Guo4

  • 1National Institute for Health and Care Research MindTech MedTech Co-operative University of Nottingham Nottingham United Kingdom.

JMIR Neurotechnology
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

Remote measurement technology (RMT) shows promise for managing chronic conditions like epilepsy, multiple sclerosis (MS), and depression. Expert validation confirmed benefits for epilepsy and depression use cases, guiding future RMT development.

Keywords:
DelphiMSRMTcentral nervous systemdepressiondepressive disorderepilepsyexpert opinionexpert panelimplementationmHealthmobile healthmobile phonemultiple sclerosisnervous system disorderneurological disorderneurologyperspectiveremote measurement technologysmartphoneuse casewearablewearable technology

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Area of Science:

  • Neurology
  • Digital Health
  • Health Technology Assessment

Background:

  • Chronic central nervous system conditions like multiple sclerosis (MS), epilepsy, and depression present challenges for traditional assessment methods.
  • Remote measurement technology (RMT) offers potential benefits for monitoring and managing these conditions.
  • Thirteen RMT use cases were previously developed across epilepsy, MS, and depression.

Purpose of the Study:

  • To evaluate the clinical utility and implementation challenges of 13 RMT use cases.
  • To prioritize RMT applications through expert consensus.

Main Methods:

  • A Delphi exercise involving an expert panel of European clinicians external to the project.
  • Two survey rounds and a follow-up interview round were conducted.
  • Data analysis focused on consensus and stability between survey rounds, with qualitative exploration of implementation issues.

Main Results:

  • High stability was observed for use case validation, but lower consensus on broader implementation issues.
  • All 5 epilepsy RMT use cases were deemed beneficial, though risk scoring was less favored.
  • All 5 depression RMT use cases showed agreement on benefits, with specific use cases like trend detection and treatment review receiving strong consensus.
  • Limited consensus was found for MS RMT use cases, potentially due to a high dropout rate of MS clinicians.

Conclusions:

  • Findings inform the prioritization of RMT use cases for future development, including clinical trials and commercialization.
  • Key priorities include RMT for accurate symptom/treatment response tracking and data for patient triage and alerts.
  • Further research should focus on cost-effectiveness and clinical validation of prioritized RMT applications.