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Development and Evaluation of an Injectable Acellular Dermal Matrix for Breast Reconstruction
Linh Thi Thuy Le1,2,3, Thuy-Tien Thi Trinh2,4, Nguyen Ngan Giang2,5
1Department of Biomedical Science, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
ACS Applied Bio Materials
|December 4, 2025
Summary
SC Fill paste, an injectable acellular dermal matrix, shows promise for breast reconstruction after oncoplastic breast-conserving surgery. This novel filler integrates well with host tissue, promoting healing and offering a stable, adaptable solution for complex defects.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Plastic Surgery
Background:
- Breast reconstruction after oncoplastic breast-conserving surgery (OBCS) faces challenges with conventional methods.
- Autologous flaps have limitations including donor site morbidity and complexity.
- Acellular dermal matrix (ADM) is a potential volume replacement, but its use in direct defect filling is underexplored.
Purpose of the Study:
- To introduce and evaluate SC Fill paste, an injectable microparticulate ADM, for breast defect reconstruction.
- To assess the biocompatibility, tissue integration, and remodeling potential of SC Fill paste.
- To provide preclinical evidence for SC Fill paste as a reconstructive filler for post-BCS defects.
Main Methods:
- SC Fill paste was developed using supercritical CO2 decellularization and micronization.
- In vitro and in vivo studies assessed tissue integration, inflammation, and ECM preservation.
- Western blot analysis confirmed low dsDNA and MHC-I protein content.
- Fibroblast infiltration, neovascularization, capsular contracture, MMP activity, and collagen expression were evaluated.
Main Results:
- SC Fill paste demonstrated efficient host tissue integration and ECM/growth factor preservation.
- Minimal inflammatory response was observed due to low dsDNA and absence of MHC-I proteins.
- Enhanced fibroblast infiltration and neovascularization were noted, with reduced capsular contracture.
- Consistent six-month remodeling effect indicated long-term stability.
Conclusions:
- SC Fill paste is a versatile and effective injectable ADM filler for breast reconstruction.
- Its properties support tissue integration, healing, and long-term stability.
- SC Fill paste offers a practical and adaptable solution for complex post-BCS defects.
