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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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The Hidden Trigger of Migraine: The Role of Intranasal Mucosal Contact Points

Murat Yaşar1, İdris Kocatürk2

  • 1Department of Otorhinolaryngology, Kastamonu University Faculty of Medicine, Kastamonu, Türkiye.

The Eurasian Journal of Medicine
|December 4, 2025
PubMed
Abstract

Insights

Intranasal mucosal contact points (MCPs) are more common in migraine patients. This study found a higher prevalence of MCPs, particularly between the middle concha and septum, in individuals with episodic migraine.

Area of Science:

  • Otolaryngology
  • Neurology
  • Medical Imaging

Background:

  • Intranasal mucosal contact points (MCPs) can trigger or worsen headaches.
  • The relationship between MCPs and migraine features requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of intranasal MCPs in patients with episodic migraine.
  • To explore the association between MCPs and specific migraine characteristics.

Main Methods:

  • Retrospective study comparing 50 migraineurs with 50 controls.
  • Computed tomography (CT) scans analyzed for intranasal MCPs and anatomical variations.
  • Migraine features assessed using Visual Analog Scale (VAS), MIDAS, and HIT-6 scores.

Main Results:

  • A significantly higher prevalence of MCPs was observed in the migraine group compared to the control group (P=.018).
  • No significant correlations were found between MCPs and age, sex, migraine aura, menstruation, attack frequency/duration, pain severity, or disability scores (VAS, MIDAS, HIT-6).

Conclusions:

  • Increased prevalence of migraine is associated with intranasal mucosal contact, especially between the middle concha and septum.
  • Further clinical research is warranted to elucidate the role of intranasal MCPs in migraine pathophysiology.
Keywords:
Headachemigrainenasal septum

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