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Implementing an Evidence-Based Neonatal Circumcision Pain Management Protocol: A Quality Improvement Initiative.

Renu Mathews Philip, Francisco Ayala, Jennifer Wilson

    Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
    |December 4, 2025
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    Implementing a new neonatal circumcision pain protocol significantly reduced infant pain scores. Nurse practitioners led this quality improvement initiative, demonstrating improved pain management and provider satisfaction.

    Keywords:
    Circumcisionpain managementquality improvement

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    Area of Science:

    • Neonatal care
    • Pain management
    • Quality improvement

    Background:

    • Lack of standardized neonatal circumcision pain management guidelines causes inconsistent care and adverse outcomes.
    • These issues can escalate healthcare costs, prolong hospital stays, and necessitate increased patient monitoring.
    • Nurse practitioners (NPs) are ideally positioned to lead evidence-based quality improvement (QI) initiatives in this area.

    Purpose of the Study:

    • To evaluate an evidence-based neonatal circumcision pain protocol throughout the entire care process, from pre-procedure to recovery.
    • Assessing the protocol's impact on neonatal pain scores and its long-term sustainability.

    Main Methods:

    • Utilized the Knowledge-to-Action framework and QI methodologies to guide the implementation and evaluation.
    • The protocol included pre-circumcision acetaminophen, white noise during the procedure, standardized pain assessment, and post-procedure pain management with acetaminophen or nonpharmacologic methods.
    • Provider compliance was crucial for the protocol's success.

    Main Results:

    • Neonatal pain scores significantly decreased from 3.14 to 1.12 (p <.001) post-implementation.
    • Process objectives were met by the third Plan-Do-Study-Act cycle and sustained over time.
    • One hundred percent of healthcare providers reported that the new protocol enhanced neonatal pain management.

    Conclusions:

    • A comprehensive strategy is essential for effective neonatal circumcision pain management.
    • This QI initiative underscores the critical role of nurse practitioner leadership in implementing evidence-based changes.
    • The protocol demonstrated significant improvements in pain reduction and provider agreement.