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Self-Assembled Large-Area Chiral Plasmonic Gold Nanoparticle Films for Highly Enhanced Enantiomer Recognition
Daiguo Tang1, Xiuhu Liu1, Jinming Bi1
1School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China.
Langmuir : the ACS Journal of Surfaces and Colloids
|December 4, 2025
Summary
Researchers developed uniform chiral gold nanoparticle substrates for highly sensitive chiral molecule detection using surface-enhanced Raman scattering (SERS). This method improves accuracy in analyzing enantiomers for applications in drug analysis and biosensing.
Area of Science:
- Plasmonics
- Chiral nanostructures
- Spectroscopy
Background:
- Surface-enhanced Raman scattering (SERS) offers potential for chiral molecule detection.
- Existing SERS methods face challenges with substrate uniformity and stability.
- Chiral plasmonic nanoparticles are key for enantioselective sensing.
Purpose of the Study:
- To develop highly uniform SERS substrates using chiral gold nanoparticles.
- To enable sensitive and accurate detection of chiral molecules.
- To overcome limitations of traditional SERS substrates.
Main Methods:
- Synthesized well-defined chiral gold nanoparticles via cysteine-induced structural distortion.
- Assembled nanoparticles into large-area, high-density chiral nanofilms using interfacial self-assembly.
- Utilized plasmon-exciton coupling for enhanced chiral field generation.
Main Results:
- Fabricated highly uniform SERS substrates with chiral gold rhombic dodecahedra.
- Achieved sensitive SERS discrimination of amino acid enantiomers (phenylalanine, tyrosine).
- Demonstrated a Raman intensity difference (DI ≈ 5) and strong linear correlation (R² ≥ 0.97) with enantiomeric excess.
Conclusions:
- The developed chiral nanofilms provide a robust platform for chiral molecular recognition.
- This approach overcomes uniformity issues in SERS substrates.
- Offers a pathway for cost-effective chiral sensing devices in drug analysis, food safety, and biosensing.
