Analysis in 3D of Hybrid Injectable Combining Hyaluronic Acid and Calcium Hydroxyapatite: Prospective Study

Area of Science:

• Aesthetic medicine and dermatology
• Facial rejuvenation techniques
• Injectable fillers

Background:

• Aging significantly impacts facial aesthetics and self-esteem.
• There is a growing demand for effective anti-aging facial treatments.
• Research is actively exploring novel solutions to mitigate facial aging effects.

Purpose of the Study:

• To evaluate the three-dimensional volume gain and facial lifting effects of HArmonyCa™ filler.
• To assess the efficacy of HArmonyCa™ in facial rejuvenation.
• To quantify changes in facial volume and tissue displacement post-injection.

Main Methods:

• Eight female patients (mean age 47) received 1.25 ml of HArmonyCa™ bilaterally.
• Injections were administered into the subcutaneous layer, posterior to facial retaining ligaments.
• Facial scanning software (Vectra™ H2) analyzed results pre-procedure and at 30, and 90 days post-procedure.

Main Results:

• Significant volume increase observed in temple and pre-jowl regions at all post-procedure times (P < 0.002).
• Zygomatic arch and mandibular branch regions showed increased volume immediately and at 90 days (P < 0.016).
• Vector analysis revealed significant tissue displacement, particularly in the mid-face, with greatest displacement indicated by red arrows (P < 0.0001).

Conclusions:

• HArmonyCa™ hybrid injectable demonstrates an immediate lifting effect.
• Progressive tissue displacement was observed, leading to reduced skin sagging.
• The filler effectively contributes to facial rejuvenation and volume restoration.