Related Experiment Video
Updated: Jun 27, 2026
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Analysis in 3D of Hybrid Injectable Combining Hyaluronic Acid and Calcium Hydroxyapatite: Prospective Study
Thallita Pereira Queiroz1, Sophia Regina Lucatelli1, Juliana Aparecida Jellmayer1
1Department of Surgery (Health Sciences), University of Araraquara - UNIARA, Rua Carlos Gomes, 1338, Centro, Araraquara, SP, CEP 14801-340, Brazil.
Background:
Aging is a process that has a major impact nowadays, influencing functional and esthetic aspects, and the population's self-esteem. Thus, researchers and companies are investing significantly in studies to control the effects of this process, especially on the face.
Purpose:
To analyze the volume gain and facial lifting effect in three dimensions after HArmonyCaTM filler application.
Methods:
Eight female patients with a mean age of 47 years received 1.25 ml of HArmonyCaTM bilaterally into the subcutaneous layer, posterior to the imaginary line that connects the main retaining ligaments of the face. The analysis of the results was performed using VectraTM H2 facial scanning software in different periods: pre-procedure, immediately after the procedure, 30 days, and 90 days post-procedure.
Results:
Volumetric analysis showed a greater volume at the immediate, 30-day, and 90-day post-procedure periods than in the pre-procedure in the temple region (P = 0.002) and pre-jowl (P = 0.001). In the zygomatic arch regions (P = 0.004) and mandibular branch (P = 0.016), a greater volume was noticed at the immediate and 90-day post-procedure periods than in the pre-procedure. In vector analysis, yellow, orange, and red arrows were higher and predominant in the middle third region of the face, posterior to the imaginary line that connects the main ligaments of the face. The red arrows, which indicate the greatest tissue displacement, were measured, and a statistically significant difference was shown between the pre-procedure and the other periods studied (P<0.0001).
Conclusion:
The hybrid injectable studied caused an immediate lifting effect associated with progressive tissue displacement, reducing skin sagging.
Level Of Evidence I:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Related Concept Videos
01:18Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...