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Updated: Jan 9, 2026
Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
Published on: June 28, 2024
Neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach
Tengyun Guo1, Kunlin Hou1, Jinqian Dong1
1The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China.
Purpose:
To evaluate the clinical efficacy of neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach.
Methods:
Clinical data of eight patients with pineal region tumors who underwent this surgical approach at our institution between January 2020 and July 2025 were retrospectively reviewed.
Results:
The cohort consisted of seven males and one female, aged 3-52 years. Gross total resection (GTR) was achieved in three patients, near-total resection (NTR) in two, and subtotal resection (STR) in three. Three patients underwent combined radiotherapy and chemotherapy. Histopathological diagnoses included three mixed germ cell tumor, two low-grade glioma, one high-grade glioma, and one mature teratoma. Two patients developed subjective memory decline. During a follow-up period of 3-29 months, seven patients resumed normal daily activities, except for one who discontinued treatment due to tumor recurrence.
Conclusion:
Neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach is a safe and effective technique, particularly for lesions extending into the third ventricle.
