Development of a statistically standardized optical digital wrist model through integrated MRI-diffuse optical...

Area of Science:

• Biomedical Optics
• Medical Imaging
• Wearable Health Technology

Background:

• Current optical health-sensing devices use simplified models, leading to inaccuracies due to anatomical complexity and optical variability.
• This necessitates the development of organ-specific optical models for reliable physiological sensing and robust clinical applications.

Purpose of the Study:

• To create a standard digital wrist (DW) optical model by integrating magnetic resonance imaging (MRI) and diffuse optical imaging (DOI).
• To enable anatomically accurate and optically realistic modeling of wrist tissues for enhanced precision in wearable optical health monitoring.

Main Methods:

• Implemented a multimodal MRI-DOI framework combining statistical MRI integration for an anatomical DW template.
• Utilized region-based time-domain diffuse optical tomography (TD-DOT) with MRI-derived priors for depth-resolved optical properties.
• Employed spatial frequency domain imaging (SFDI) to acquire high-resolution optical properties of superficial skin layers.

Main Results:

• Region-based TD-DOT reconstruction showed high accuracy with mean errors below 9.63% for optical properties.
• Phantom experiments validated TD-DOT and SFDI performance, with SFDI yielding lower errors for superficial layers.
• In vivo optical property measurements demonstrated strong agreement with literature values, confirming methodology reliability.

Conclusions:

• Established a standard DW template and an in vivo optical structure acquisition methodology.
• Transitioned biosensing models from homogeneous approximations to anatomically layered models.
• The approach enhances customization, dynamic adaptability, and clinical validity of biosensing technologies.