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Astaxanthin-Based Biomaterials for Tissue Repair and Drug Delivery Systems.

Yibing Wang¹, Huaqian Xue¹, Chuchu Sun²

¹Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang 310015, China.

Biomaterials Research

|December 5, 2025

Summary

Astaxanthin (AST) shows promise in biomedical applications due to its antioxidant and anti-inflammatory properties. Stabilizing AST with biomaterials like nanoliposomes enhances its therapeutic potential and overcomes instability challenges.

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Area of Science:

Biomaterials Science
Pharmacology
Biomedical Engineering

Background:

Astaxanthin (AST) is a potent bioactive compound with significant antioxidant, anti-inflammatory, and anti-apoptotic properties.
Its chemical instability currently limits its widespread biomedical applications.
AST has shown potential in regenerative tissue engineering and targeted drug delivery.

Purpose of the Study:

To provide a comprehensive review of astaxanthin (AST).
To examine the mechanisms of action of AST.
To discuss the development and biomedical applications of AST-based biomaterials.

Main Methods:

Review of existing literature on astaxanthin and biomaterial stabilization techniques.
Analysis of various multifunctional biomaterials used for AST stabilization (e.g., nanoliposomes, nanoparticles, glass microspheres, algal calcium beads).
Evaluation of the properties and therapeutic efficacy of AST-loaded biomaterials.

Main Results:

Multifunctional biomaterials effectively stabilize AST, enhancing its therapeutic efficacy.
AST-loaded biomaterials exhibit excellent properties for diverse biomedical applications.
Various biomaterials, including nanoliposomes and nanoparticles, are suitable for AST stabilization.

Conclusions:

Stabilizing astaxanthin with biomaterials is crucial for overcoming its instability and expanding its biomedical applications.
AST-based biomaterials hold significant potential in regenerative medicine and drug delivery.
Further research is needed to optimize biomaterial design for enhanced clinical translation.