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Multiscale aggregation materials for disease therapy and bioanalysis.

Yihang Zhu¹, Hao Tang¹, Xingyu Jiang¹

¹Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China. tangh@sustech.edu.cn.

Chemical Communications (Cambridge, England)

|December 5, 2025

Summary

This summary is machine-generated.

This review explores multiscale aggregation materials for biomedical applications, including antimicrobial therapy, bioanalysis, and drug delivery. These materials offer innovative solutions for disease treatment and diagnostics.

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Chemical aggregates exist at various scales, from molecules to macroscopic systems.
These aggregates possess diverse functionalities applicable to biomedical purposes.
Multiscale aggregation materials offer a strategic approach for innovative disease treatment and bioanalysis.

Purpose of the Study:

To review recent progress in utilizing aggregation materials from a multiscale perspective.
To highlight the discovery and application of small molecules, nanoscale, and mesoscale aggregation materials.
To discuss challenges and future directions for the practical translation of aggregation materials.

Main Methods:

Literature review of recent advancements in aggregation materials.
Focus on multiscale aggregation strategies (small molecules, nanoscale, mesoscale).
Exploration of applications in antimicrobial therapy, bioanalysis, and drug delivery.

Main Results:

Aggregation materials have been discovered at molecular, nanoscale, and mesoscale levels.
These materials demonstrate potential in antimicrobial therapy, bioanalysis, and drug delivery.
Microfluidics and chemical synthesis are key methods for creating nanoscale aggregation materials.

Conclusions:

Multiscale aggregation materials present a powerful strategy for biomedical innovation.
Further research is needed to address current challenges and facilitate practical translation.
Future directions involve optimizing material design and application for clinical use.