Related Experiment Video
Updated: Jan 9, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases
Mohammad Vakili-Ojarood1, Ahmad Shirinzadeh-Dastgiri2, Mojtaba Meybodian3
1Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Cancer Investigation
|December 5, 2025
Summary
The p53 rs1042522 polymorphism
Area of Science:
- Genetics and Oncology
- Molecular Epidemiology
Background:
- The p53 gene is a critical tumor suppressor.
- Genetic variations like the p53 rs1042522 polymorphism may influence cancer susceptibility.
- Thyroid cancer is a significant global health concern.
Purpose of the Study:
- To conduct a meta-analysis on the association between the p53 rs1042522 polymorphism and thyroid cancer risk.
- To explore potential heterogeneity and subgroup effects.
Main Methods:
- Meta-analysis of 18 case-control studies.
- Inclusion of 2,116 thyroid cancer cases and 4,017 controls.
- Statistical analysis to determine overall association and heterogeneity.
Main Results:
- The C allele of the p53 rs1042522 polymorphism was associated with an increased risk of thyroid cancer (OR=1.572, p=0.024).
- Significant heterogeneity was observed across studies (I²=94.15%).
- Subgroup analyses revealed protective effects in Caucasian, Asian, and mixed populations, and for Follicular and Differentiated Thyroid Carcinomas.
Conclusions:
- The p53 rs1042522 polymorphism's association with thyroid cancer is complex and population-dependent.
- While the C allele may generally increase risk, specific ethnic groups and thyroid cancer subtypes exhibit protective associations.
- Further research is needed to elucidate the mechanisms underlying these varied genetic effects.
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