AIEgen-Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Area of Science:

• Biomedical Engineering
• Materials Science
• Infectious Disease Control

Background:

• The recent monkeypox outbreak highlights the urgent need for effective early warning and treatment strategies.
• Current mechanisms for monkeypox prevention and control are insufficient to address its rapid spread and high mortality rate.

Purpose of the Study:

• To develop an advanced early warning and precision treatment system for monkeypox.
• To integrate aggregation-induced emission luminogen (AIEgen)-active monitoring with photodynamic therapy (PDT) for comprehensive monkeypox management.

Main Methods:

• Development of a sprayable AIE@LD system combining a liquid dressing with an AIEgen.
• Utilizing low-power white light photodynamic therapy (PDT) for in vivo viral eradication and lesion healing.
• Incorporation of dual optical channels with smartphone image recognition and a cloud platform for infection monitoring and data transmission.

Main Results:

• In vivo tests demonstrated rapid viral eradication and lesion healing within one week using 1-minute low-power white light PDT.
• The integrated system effectively combines image analysis, data transmission, infection monitoring, and PDT.
• The system provides a comprehensive solution for detecting, monitoring, treating, and interrupting monkeypox transmission.

Conclusions:

• The developed AIEgen-active monitoring and PDT system offers a promising approach for intelligent monkeypox prevention and control.
• This technology can significantly reduce the medical burden associated with monkeypox epidemics.
• The system provides innovative technological assistance for intelligent public health management of infectious diseases.