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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
856
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
282
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
778
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

323
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Donor Urinary Biomarkers and the Prediction of Deceased Donor Allograft Function.

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Updated: Jan 9, 2026

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
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Kidney Biorepositories: Valuable Tools Advancing Acute Kidney Injury Research.

Leslie S Gewin1,2, Chirag Parikh3, Sanjay Jain1

  • 1Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri.

Kidney360
|December 5, 2025
PubMed
Summary

Biorepositories are vital for acute kidney injury (AKI) research, offering essential biological specimens and patient data. This summary guides researchers on building and utilizing these critical resources for scientific advancement.

Keywords:
AKICKDchronic kidney diseasechronic rejectionchronic renal failurechronic renal insufficiency

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Area of Science:

  • Nephrology
  • Biomedical Research
  • Biobanking

Background:

  • Biorepositories, which store biological specimens and patient data, are crucial for advancing acute kidney injury (AKI) research.
  • The American Society of Nephrology's AKINow Basic Science Workgroup hosted a webinar to discuss the importance and practicalities of kidney biorepositories.

Purpose of the Study:

  • To highlight the importance of biorepositories in supporting AKI research, particularly for early-stage investigators.
  • To provide guidance on establishing new kidney biorepositories, including logistical considerations.
  • To inform researchers on leveraging existing biorepositories and the benefits/trade-offs of creating new ones.

Main Methods:

  • Summary of a webinar discussion featuring expert panelists.
  • Focus on practical aspects of biorepository development and utilization.
  • Inclusion of details on existing biorepository resources.

Main Results:

  • Biorepositories significantly support AKI research by providing critical data and specimens.
  • Key logistical factors for establishing biorepositories were identified.
  • The webinar outlined the advantages and disadvantages of using existing versus creating new biorepositories.

Conclusions:

  • Kidney biorepositories are indispensable tools for accelerating AKI research.
  • Investigators are encouraged to utilize existing biorepositories and consider establishing new ones with informed guidance.
  • Effective use and development of biorepositories can advance nephrology research and support early-stage investigators.