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Related Experiment Video

Updated: Jan 9, 2026

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
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Programmable Photothermal and Pyroelectric Responses in a Flexible PVDF-Based Hybrid Film for Stimuli-Responsive

Zongguang Liu1, Hongyu Wu1, Haotian Wu1

  • 1College of Physics Science and Technology/Microelectronics Industry Research Institute, Yangzhou University, Yangzhou 225009, P. R. China.

ACS Biomaterials Science & Engineering
|December 5, 2025
PubMed
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Researchers developed a novel soft film for tissue regeneration, combining thermal and electrical stimulation. This programmable film accelerates healing in frostbite models, offering potential for advanced bioelectronic devices.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Soft Electronics

Background:

  • Tissue regeneration often uses external thermal and electrical stimuli.
  • Integrating these into a single, programmable soft film is a significant challenge.
  • Existing methods lack a unified, controllable platform for dual-mode stimulation.

Purpose of the Study:

  • To create a flexible, photoresponsive hybrid film capable of dual-mode thermal and electrical stimulation.
  • To demonstrate the film's efficacy in promoting tissue repair and regeneration.
  • To explore its potential for on-demand bioelectronic interfaces and soft therapeutic devices.

Main Methods:

  • Fabrication of a poly(vinylidene fluoride) (PVDF) matrix with polydopamine-coated BaTiO3 nanoparticles via spin-coating.
Keywords:
near-infrared-triggered healingphotoresponsive hybrid filmprogrammable dual-mode stimulationstimuli-responsive wound dressing

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  • Utilizing near-infrared irradiation for both photothermal output and triggering pyroelectric response.
  • Testing the film's performance in a mouse frostbite model for rewarming and tissue repair.

    • Main Results:

    • The composite film (PVDF/PDA@BTO) demonstrated dual-mode functionality under near-infrared irradiation.
    • Stable photothermal outputs maintained target temperatures (37 or 42 °C).
    • Pulsed irradiation triggered pyroelectric response, generating tunable voltage outputs (∼250 mV with 0.25 s pulse).

    Conclusions:

    • A facile strategy for programmable, multifunctional polymer-inorganic hybrid films was developed.
    • The film successfully accelerated rewarming and tissue repair in a preclinical model.
    • This technology holds promise for advanced bioelectronic interfaces and soft therapeutic applications.