Long Noncoding RNA function prediction via multiview cross-contrastive learning combined with multiscale semantic...

Understanding long noncoding RNA (lncRNA) function is essential for revealing molecular mechanisms and developing effective therapies for complex diseases, as lncRNAs play important regulatory roles in many disease-related biological processes. However, existing lncRNA function predictors struggle to extract discriminative features from multimodal omics data and to model the semantic and topological structure of the gene ontology (GO), which severely limits their ability to achieve biologically meaningful and functionally informative predictions. To address these challenges, we propose a novel framework for lncRNA function prediction, namely MiCLSAO. Firstly, MiCLSAO utilizes multiview cross-contrastive learning with attention mechanisms to extract highly discriminative lncRNA features from diverse omics similarity networks. Secondly, graph convolutional networks are applied to learn initial features of GO terms, while multiscale topological and semantic relationships are incorporated to adaptively refine term representations. Finally, an lncRNA function predictor is developed by dynamically integrating the representations of lncRNAs and GO terms using a Kolmogorov-Arnold network. Extensive experiments demonstrate that MiCLSAO consistently outperforms state-of-the-art methods across multiple metrics, with significant capability to recover known functions and uncover novel ones. Moreover, MiCLSAO demonstrates remarkable practical utility and potential value by providing more functionally informative annotations for lncRNAs.