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Related Experiment Video

Updated: Jul 9, 2026

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
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Research progress on laser surface microstructuring systems for drug storage and release from orthopedic implants.

Yumei Bao1,2, Zhiwei Chen1, Heng Zhang1

  • 1College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, People's Republic of China.

Biomedical Materials (Bristol, England)
|December 5, 2025
PubMed
Summary

Laser technology precisely controls micro/nano structures on orthopedic implants for enhanced drug delivery, combating infection and improving osseointegration for better surgical outcomes.

Keywords:
additive manufacturingdrug storage/releaselaser processingmicro–nano structuresorthopedic implants

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Laser Processing Technology

Background:

  • Postoperative infection and poor osseointegration are critical challenges in orthopedic implant failure.
  • Drug storage and release functions integrated into implants offer a promising solution.
  • Micro/nano topological structures are crucial for efficient drug loading and controlled release.

Purpose of the Study:

  • To systematically review the application of laser technology in creating drug storage and release microstructures on orthopedic implants.
  • To highlight the role of laser processing in enhancing implant functionality for improved patient outcomes.
  • To analyze current challenges and future directions in this field.

Main Methods:

  • Review of literature on implant surface microstructure design and preparation methods.
  • Focus on ultrafast laser techniques for fabricating micro/nano topological structures.
  • Emphasis on laser additive manufacturing for creating complex scaffolds with graded porosity.

Main Results:

  • Laser technology enables precise control over micro/nano structures for antibacterial and sustained drug release.
  • Laser additive manufacturing facilitates the creation of implant scaffolds with enhanced drug-loading capacity.
  • Graded porosity structures achieved via laser processing allow for on-demand drug release.

Conclusions:

  • Laser processing is a key technology for developing advanced orthopedic implants with integrated drug delivery systems.
  • Tailoring micro/nano structures using lasers can significantly improve implant performance and reduce failure rates.
  • Further research into laser-based fabrication holds potential for next-generation orthopedic solutions.