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Updated: Jan 9, 2026

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Plasmatic biochemical changes in COVID-19: Relevant markers that reflect patient genotypic predisposal
Jeferson S Ursulino1, Eloiza L L Tanabe2, Aldilane L X Marques2
1Nucleus of Analysis and Research in Nuclear Magnetic Resonance - NAPRMN, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Brazil.
Background:
The emergence of COVID-19 as a global health threat, particularly exacerbated in pre-existing chronic conditions, underscores the imperative for continuous exploration of biomarkers to enhance clinical management.
Methods:
This study employs multidimensional techniques, analyzing COVID-19 and control blood samples through plasma NMR, Raman spectroscopy, and leukocyte SNP genotyping.
Results:
NMR metabolomics identifies heightened levels of L-lactic acid, D-glucose, VLDL/LDL, L-glutamic acid, and 1-methyl-histidine in COVID-19, alongside reduced levels of L-alanine and L-histidine. ROC curves exhibit robust discriminatory power, affirming the model's efficacy in distinguishing COVID-19 from control samples. Raman spectroscopy unveils bands associated with molecular vibrations of amino acids, lipids, and carotenoids in COVID-19. SNP genotyping reveals the rs2070788-TMPRSS2 association with elevated COVID-19 risk and rs8259-CD147 association with protective effects.
Conclusions:
Our findings provides a comprehensive investigation of acute COVID-19, highlighting novel biomarkers, particularly the correlation between 1-methyl-histidine levels and the TMPRSS2 GG + AG genotype.
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