Related Experiment Video
Updated: Jan 9, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
A novel method for the mechanochemical synthesis of unsymmetrical disulfides using phosphorodithioic acid derivatives
Mikołaj Walter1, Agata Grobelna1, Janusz Rachoń1
1Department of Organic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland.
Abstract:
In this study, we report the efficient synthesis of unsymmetrical disulfides using a mechanochemical ball-milling approach. This research successfully yielded alkyl-alkyl, alkyl-aryl, and aryl-aryl unsymmetrical disulfides without any detectable formation of symmetrical products. Additionally, we eliminated the use of solvent in the reaction mixture and replaced triethylamine with the more environmentally friendly cesium carbonate as a base. These results represent a significant advancement in the modern synthesis of disulfides, which have applications in pharmacology.
Related Concept Videos
Preparation and Reactions of Sulfides
Preparation and Reactions of Thiols
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction

