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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Progress and Future Perspectives of Treg Cell Therapy

Kehua Fang1, Jinbao Zong2, Xiaotian Chang3,4

  • 1Clinical Laboratory, The Affiliated Hospital of Qingdao University, 266000 Qingdao, Shandong, China.

Frontiers in Bioscience (Landmark Edition)
|December 6, 2025
PubMed

The important immunoregulatory roles of regulatory T cells (Tregs) include fostering tolerance to infections, controlling immune surveillance, and curtailing autoimmunity. Years of research have not only generated abundant knowledge in the field of Treg biology but also enabled the initial application of Tregs in cell therapy. However, most data in this field are obtained from laboratory animals and in vitro experiments. This review provides an updated summary and the latest understanding of Treg-targeting cell therapy. We introduce the unique traits of Tregs, review animal experiments and clinical trials on Treg injections, discuss limitations of Treg applications, and consider future perspectives on Treg-based therapies. Overall, the safety and potential efficacy of Tregs will broaden the scope of cell-based treatments.

Keywords:
Tregs (regulatory T cells)cell therapyimmunodeficiencyimmunoregulationimmunotherapy

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