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Lysosomal activation leaves a lasting memory.

Amaresh Chaturbedi1, Charles Lowell Heinke1, Siu Sylvia Lee1

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.

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|December 6, 2025
PubMed
Summary
This summary is machine-generated.

Lysosomes prepare Caenorhabditis elegans offspring for stress by inducing histone production that is transmitted to the germline, promoting longevity. This study reveals lysosomes as key in linking metabolism, chromatin, and epigenetic inheritance.

Keywords:
H3.3 (HIS-71)H3K79 methylationaginglysosomal lipolysistransgenerational inheritance

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Area of Science:

  • Cell Biology
  • Epigenetics
  • Genetics

Background:

  • Lysosomes are primarily known for their role in cellular degradation.
  • Emerging evidence suggests lysosomes have functions beyond catabolism.
  • Understanding lysosome function in stress response and inheritance is crucial.

Purpose of the Study:

  • To investigate the role of lysosomes in preparing Caenorhabditis elegans offspring for stress.
  • To elucidate the mechanism by which lysosomes influence germline and inheritance.
  • To establish the link between lysosomal activity, chromatin modification, and longevity.

Main Methods:

  • Studied lysosomal activation in Caenorhabditis elegans.
  • Analyzed histone H3.3 production and localization.
  • Investigated histone methylation at K79.
  • Assessed the transmission of epigenetic factors to offspring.

Main Results:

  • Lysosomal activation induces somatic histone H3.3 production.
  • Histone H3.3 is transferred from somatic cells to the germline.
  • Histone H3.3 is methylated at K79 in the germline.
  • This process is linked to the transmission of longevity.

Conclusions:

  • Lysosomes play a critical role in stress preparation for offspring in Caenorhabditis elegans.
  • Lysosomes act as a conduit for epigenetic inheritance, linking metabolism and chromatin.
  • Somatic histone production and germline methylation mediated by lysosomes transmit longevity traits.