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Updated: Jun 27, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Sinonasal osteoblastoma: a case series and comprehensive literature review
Goran Latif Omer1,2, Aland Salih Abdullah3, Sahand Soran Ali4
1Department of Clinical Sciences, College of Medicine, University of Sulaimani, Sulaymaniyah, KRI, 46001, Iraq. goran.omer@univsul.edu.iq.
Purpose:
Sinonasal osteoblastoma is a rare benign tumor that can involve critical structures like the skull base and orbit. This study presents a case series and literature review to describe clinical features, surgical management, and outcomes.
Methods:
Five patients with sinonasal osteoblastoma were treated endoscopically between 2020 and 2025. Clinical data, imaging, surgical approach, histopathology, and follow-up outcomes were reviewed. A PubMed search was conducted to identify previously reported cases.
Results:
Patients ranged from 12 to 57 years old. Tumors most commonly involved the ethmoid sinus and presented with nasal obstruction, headache, or epistaxis. Four underwent total endoscopic resection; one had subtotal removal due to frontal sinus involvement. Histopathology revealed three conventional and two aggressive osteoblastomas. No recurrences or major complications occurred over a follow-up of two to five years.
Conclusion:
Endoscopic resection appears to be a safe and effective approach for sinonasal osteoblastomas, even in cases with skull base or orbital extension. This series supports the growing role of minimally invasive surgery in managing these uncommon tumors.
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