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Personalized Reference Intervals Versus Indirectly Estimated Population-Based Reference Intervals for Hematology
Ozlem Demirelce1, Berrin Bercik Inal2, Abdurrahman Coşkun3
1Department of Medical Biochemistry, University of Health Sciences, Göztepe Training and Research Hospital, Istanbul, Turkey.
Background:
Interpretation of laboratory data is a comparative process that requires reliable reference intervals (RIs) to support clinical decision-making. Although population-based reference intervals (popRIs) are commonly used for this purpose, more accurate interpretation can be achieved using RIs derived from an individual's own data-that is, personalized reference intervals (prRIs). In this study, we estimated prRIs for common hematology parameters and compared them with popRIs indirectly derived from laboratory data.
Method:
popRIs were estimated for a total of 17 complete blood count (CBC) subparameters using patient laboratory data. prRIs for the same parameters were calculated using longitudinal data from 200 healthy individuals, based on a prediction interval model. Additionally, the reference interval index (RII) was calculated as the ratio of the range of prRIs to the range of popRIs for each measurand.
Results:
prRIs calculated for CBC parameter differed from the corresponding popRIs. The median of RII varied from 0.41 for eosinophils to 2.97 for platelet distribution width (PDW).
Conclusion:
We concluded that the prRIs of the CBC parameters differ from their corresponding popRIs, and that prRIs should be used for a more accurate interpretation of patients' CBC results.
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