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BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.

Satomi F Ono¹, Rikito Furukawa¹, Ingrid Rosenburg Cordeiro¹

¹School of Life Science and Technology, Institute of Science Tokyo, Yokohama, Japan.

Development, Growth & Differentiation

|December 8, 2025

Summary

This summary is machine-generated.

Bone morphogenetic protein (BMP) signaling regulates programmed cell death in developing chicken limbs by controlling reactive oxygen species (ROS) production. This finding clarifies the link between BMP, ROS, and limb development.

Keywords:

antioxidants bone morphogenetic proteins limb buds reactive oxygen species regulated cell death

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Area of Science:

Developmental Biology
Cell Biology
Molecular Biology

Background:

Programmed cell death is crucial for embryonic limb development in amniotes.
Bone morphogenetic protein (BMP) signaling induces interdigital cell death.
The role of reactive oxygen species (ROS) in BMP-mediated cell death is not fully understood.

Purpose of the Study:

To investigate the relationship between BMP signaling and ROS production in embryonic limb development.
To identify molecular mechanisms linking BMP signaling to ROS production and cell death.

Main Methods:

Transcriptome analysis to identify candidate genes.
Pharmacological inhibition of NADPH oxidase.
Assessment of ROS levels and cell death in chicken hindlimb interdigital regions.

Main Results:

BMP signaling modulates ROS production, which is essential for interdigital cell death.
BMP signaling upregulates ROS-generating enzymes (e.g., Nox2, Nox4) and downregulates ROS-scavenging enzymes (e.g., Sod1).
Inhibition of NADPH oxidase reduces ROS levels and cell death, indicating its partial dependence.

Conclusions:

BMP signaling regulates programmed cell death in limb development, partly through modulating redox homeostasis.
The findings elucidate a novel mechanism involving BMP-mediated ROS production in shaping limb morphology.