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Case Report: Multifocal Epithelial Hyperplasia in Two Yemeni Patients With Khat Chewing Habits
Layla Hafed1,2, Munia Mahmood Shamsheer3, Islam Alobaidy3
1Department of Oral Medicine and Diagnostic Science, Faculty of Dentistry, Saba University, Sana'a, Yemen.
Case Reports in Dentistry
|December 8, 2025
Summary
Multifocal epithelial hyperplasia (MEH), a rare HPV-associated condition, typically affects children. This report details two adult cases of MEH on the lips, highlighting potential risk factors and diagnostic considerations.
Area of Science:
- Oral Pathology
- Dermatology
- Virology
Background:
- Multifocal epithelial hyperplasia (MEH) is a rare, benign oral condition linked to human papillomavirus (HPV).
- It predominantly affects children and adolescents, with intraoral lesions on the labial/buccal mucosa and tongue.
- MEH is uncommon in Asian regions, including Yemen.

