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Updated: Jan 9, 2026
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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
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Genome-wide association study of neuropathic pain
Mari Spildrejorde1,2, Øystein Dunker1,3,4, Sara Maria Allen3
1Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Pain
|December 8, 2025
Summary
Genetic factors influencing neuropathic pain are complex. This study found no genome-wide significant variants but identified potential associations with pain intensity, suggesting further research is needed.
Area of Science:
- Genetics
- Neuroscience
- Pain Research
Background:
- Neuropathic pain is a complex, multifactorial chronic condition.
- The genetic underpinnings of neuropathic pain are not well understood.
- Genetic susceptibility plays a role in neuropathic pain development.
Purpose of the Study:
- To investigate genetic variants associated with neuropathic pain presence and intensity.
- Utilized genome-wide association analyses in a well-phenotyped cohort.
Main Methods:
- Genome-wide association studies (GWAS) were performed on 1146 individuals with peripheral neuropathy.
- Genotyping utilized the Illumina Global Screening Array.
- Analyses tested associations with neuropathic pain presence and intensity.
Main Results:
- No significant associations were found at the genome-wide significance level (P < 5 × 10-8).
- Three single nucleotide polymorphisms (SNPs) near CHRDL1, MCF2L, and a long non-coding RNA showed subthreshold associations (P < 10-6) with pain intensity.
- Targeted candidate gene analysis did not yield significant results.
Conclusions:
- The genetic architecture of neuropathic pain is complex, challenging the identification of common variants with significant effects.
- Subthreshold associations with genes involved in synaptic plasticity warrant further investigation.
- Larger studies with refined phenotyping are crucial for validating findings and understanding genetic contributions to neuropathic pain.
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