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Behavioural therapy for inter-episode bipolar symptoms: a multiple baseline case series evaluation
Kim Wright1, Sandra Bucci2,3, Iona Cairns4
1Department of Psychology, University of Exeter, Perry Road, Exeter, EX4 4QG, UK. K.A.Wright@exeter.ac.uk.
International Journal of Bipolar Disorders
|December 8, 2025
Summary
The STABILISE therapy, an emotion regulation intervention for bipolar disorder, shows promise in managing inter-episode symptoms. This initial study found the treatment to be safe, feasible, and acceptable, with most participants showing overall improvement.
Area of Science:
- Psychiatry and Behavioral Sciences
- Clinical Psychology
- Mental Health Interventions
Background:
- Bipolar disorder patients often experience persistent low mood or mood instability between major affective episodes.
- The STABILISE programme is an adapted individual behavioral therapy focusing on emotion regulation for these inter-episode symptoms.
Purpose of the Study:
- To evaluate the safety, feasibility, and acceptability of the STABILISE therapy.
- To explore the potential clinical benefits and patterns of change associated with the intervention.
Main Methods:
- A randomized multiple baseline case series design involving 12 individuals with inter-episode bipolar symptoms.
- Participants received up to 22 sessions of STABILISE therapy over 7 months, with staggered start times.
- Symptom, mood lability, recovery, and quality of life measures were collected at multiple time points.
Main Results:
- All 12 participants completed the therapy, reporting high satisfaction with no therapy-related adverse events.
- Nine out of 12 participants demonstrated an overall pattern of clinical improvement.
- One participant showed reliable deterioration on a single outcome measure, while none showed overall deterioration.
Conclusions:
- The STABILISE therapy demonstrates preliminary support for its feasibility, acceptability, and safety in managing inter-episode symptoms of bipolar disorder.
- Further research in a larger sample and a randomized controlled trial is warranted to confirm these findings.
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