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Visualization of the Gallbladder on 177 Lu-FAP-2286 SPECT/CT Imaging : A Potential Pitfall
Xinyi Lin1,2,3,4, Yang Xie1,2,3,4, Wenjuan Li4,5
1Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University.
None:
Fibroblast activation protein (FAP) is a membrane-bound protease predominantly expressed on the surface of cancer-associated fibroblasts activated within the solid tumor microenvironment, while its expression remains minimal in normal tissues. Following radiolabeling, FAP-2286 has demonstrated favorable diagnostic performance and promising therapeutic potential in cancer. The image illustrates the accumulation of 177 Lu-FAP-2286 in the gallbladder, but correlative imaging and knowledge of the radiopharmaceutical helped to avoid a diagnostic pitfall.
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