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Updated: Jun 19, 2026

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

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Enhancing Digital Microfluidics: A Comprehensive Investigation into the Performance of Slippery Liquid-Infused Porous

Neeti Kalyani¹, Rahul Singh¹, Ankita Mishra

¹DTU Bioengineering, Technical University of Denmark, Kongens, Lyngby 2800, Denmark.

ACS Applied Materials & Interfaces

|December 8, 2025

Summary

This summary is machine-generated.

Slippery liquid-infused porous surfaces (SLIPS) enhance digital microfluidics. The M1 membrane with silicone oil showed optimal droplet manipulation and reduced biofouling, advancing microfluidic device performance.

Keywords:

Teflon antifouling biofouling contact angle digital microfluidics silicone oil slippery liquid infused porous surfaces (SLIPS)

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Area of Science:

Materials Science
Surface Engineering
Microfluidics

Background:

Slippery liquid-infused porous surfaces (SLIPS) offer potential in digital microfluidics for droplet manipulation and biofouling prevention.
Existing research lacks systematic optimization of SLIPS for microfluidic applications.

Purpose of the Study:

To investigate the fabrication and performance of SLIPS using different Teflon membranes and oils for digital microfluidics.
To identify optimal SLIPS configurations for enhanced droplet actuation and reduced biofouling.

Main Methods:

Fabrication of SLIPS using two distinct Teflon membranes (M1 and another) infused with three different oils: Silicone oil, Krytox oil, and Fluorinert FC40.
Evaluation of SLIPS performance in digital microfluidics, including actuation voltage and droplet speed.
Assessment of antifouling properties by measuring bacterial and protein adhesion compared to untreated Teflon.

Main Results:

The M1 membrane infused with silicone oil exhibited superior performance, requiring a low actuation voltage of 170 V and achieving a droplet speed of 220 mm/min.
These optimized SLIPS demonstrated significant reduction in bacterial and protein adhesion, indicating effective antifouling properties.
The study identified specific membrane-oil combinations suitable for advanced digital microfluidic applications.

Conclusions:

The M1 membrane with silicone oil represents a highly effective SLIPS configuration for digital microfluidics, balancing actuation efficiency and antifouling capabilities.
These findings provide critical insights for the rational design and engineering of high-performance SLIPS.
This work paves the way for the development of more robust and scalable digital microfluidics platforms.