Some biophysical and biochemical properties of poly(phthaloyl L-lysine) microcapsules containing hemolysate

Measurements of oxygen equilibrium, zeta-potential, resistance to flow, carbonic anhydrase activity, and catalase activity were made on sheep erythrocyte hemolysate-loaded poly(phthaloyl L-lysine) microcapsules (artificial red blood cells) prepared by an interfacial polycondensation technique. The measurements revealed that oxygen dissociation equilibrium, zeta-potential, and carbonic anhydrase activity of the microcapsules are almost the same as those of sheep erythrocytes, while the microcapsules have a higher resistance to flow and a lower catalase activity than the erythrocytes. Possible ways of improving the properties of the microcapsules were suggested.