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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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MoO3-Naringin-Loaded CMC/PVA/PVP Patch: A Rapid Biofunctional Wound Dressing.

Suresh Krishna Pandian1, Marvaan Ms1, Samantha Raj Sah1

  • 1Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur 603203, India.

ACS Applied Bio Materials
|December 9, 2025
PubMed
Summary

A novel polymer patch containing molybdenum oxide nanoparticles and naringin effectively treats chronic wounds. This advanced wound dressing promotes rapid healing and combats infection, showing 91% closure in 15 days.

Keywords:
antibacterial activitycarboxymethyl cellulosemolybdenum oxidenaringinpoly(vinyl alcohol)polyvinylpyrrolidonewound dressingwound healing

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Wound Healing Research

Background:

  • Chronic wounds present significant challenges due to prolonged healing times and high infection rates.
  • Effective wound management requires advanced dressings with potent antibacterial properties to overcome infection barriers.
  • Current treatments often struggle to address the complex healing environment of chronic, infected wounds.

Purpose of the Study:

  • To develop and evaluate a novel polymeric wound dressing incorporating molybdenum oxide (MoO3) nanoparticles and naringin.
  • To assess the antibacterial efficacy and wound healing potential of the fabricated carboxymethyl cellulose (CMC), poly(vinyl alcohol) (PVA), and polyvinylpyrrolidone (PVP) based patch.
  • To investigate the physicochemical properties and in vivo performance of the advanced wound dressing.

Main Methods:

  • Molybdenum oxide (MoO3) nanoparticles synthesized via wet chemical method and characterized using XRD, FTIR, and TEM.
  • Antibacterial activity of MoO3 evaluated through diffusion, colony count, growth curve, and biofilm disruption assays.
  • Fabricated polymer patches (CMC/PVA/PVP with and without MoO3 and naringin) assessed for biocompatibility, swelling, degradation, porosity, drug release, WVTR, MTT, and scratch assays. In vivo study conducted on Wistar rats using a full-thickness excisional wound model.

Main Results:

  • Molybdenum oxide (MoO3) nanoparticles exhibited significant antibacterial activity and biofilm disruption capabilities.
  • The CMC/PVA/PVP/MoO3/naringin polymer patches demonstrated favorable biocompatibility, swelling, degradation, and drug release profiles.
  • In vivo studies showed the CMC/PVA/PVP/MoO3/naringin patch achieved 91% wound closure within 15 days in a rat model.

Conclusions:

  • The developed polymeric patch containing molybdenum oxide (MoO3) nanoparticles and naringin is a promising candidate for treating chronic infected wounds.
  • The combination of MoO3 nanoparticles and naringin in the CMC/PVA/PVP matrix enhances antibacterial properties and accelerates wound healing.
  • This advanced wound dressing offers a potential solution for improving patient outcomes in chronic wound management.