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Updated: Jan 9, 2026

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Copper-Catalyzed Regio- and Enantioselective Acylation of 1,3-Enynes
Jing He1, Wan Seok Yoon1, Jaesook Yun1
1Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea.
Abstract:
This work discloses the first enantioselective copper-catalyzed acylation of 1,3-enynes with acyl fluorides. The reaction proceeds via an enantioenriched allenylcopper species that is chemoselectively generated from enynes in the presence of competing acyl fluorides. The resulting products bearing all-carbon quaternary centers are obtained with high enantioselectivity through a copper-oxygen-coordinated transition state. The method provides a practical and scalable strategy for asymmetric C-C bond formation with broad functional group tolerance.
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