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Fungal neglected tropical diseases
1Dermatology Department, Brighton General Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Clinical and Experimental Dermatology
|December 9, 2025
Summary
Fungal neglected tropical diseases (NTDs) like mycetoma, chromoblastomycosis, and sporotrichosis cause chronic, destructive skin infections. Effective management requires long-term antimicrobial and surgical treatments due to their challenging nature.
Area of Science:
- Mycology
- Infectious Diseases
- Tropical Medicine
Background:
- Neglected tropical diseases (NTDs) encompass a group of infections that disproportionately affect impoverished populations.
- Fungal infections represent an underappreciated category of NTDs, often leading to significant morbidity.
Purpose of the Study:
- To provide a comprehensive overview of fungal-originating NTDs.
- To highlight the clinical characteristics and management challenges of mycetoma, chromoblastomycosis, and sporotrichosis.
Main Methods:
- Literature review of fungal NTDs.
- Synthesis of information on epidemiology, clinical presentation, and treatment strategies.
Main Results:
- Mycetoma, chromoblastomycosis, and sporotrichosis are identified as key fungal NTDs.
- These diseases manifest as chronic, destructive infections of the skin and subcutaneous tissues.
- They can result in disfigurement and long-term disability.
Conclusions:
- Fungal NTDs pose a significant global health burden.
- Management is complex, often necessitating prolonged antimicrobial therapy combined with surgical interventions.
- Further research and integrated control strategies are crucial for addressing these debilitating conditions.
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