An ROS/viscosity dual-activated nanoprobe with CD44-targeting ability for NIR-II imaging of early atherosclerotic
Shuai Zhao1, Ruixin Liu1, Yanxiang Gao2
1State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, PR China. sunfang60@yeah.net.
Chemical Communications (Cambridge, England)
|December 9, 2025
Abstract
None:
We developed a NIR-II fluorescent nanoprobe, DCy-BOH@BSA-HA, for targeted identification of atherosclerotic (AS) plaques. The probe remains quiescent initially but is dually activated by the plaque microenvironment-specifically elevated ROS and viscosity-while (hyaluronic acid) HA mediates CD44 targeting. This strategy enabled precise NIR-II fluorescence imaging of aortic plaques in a murine AS model.
