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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jun 12, 2026

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

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A Remotely Actuated Multifunctional Nitinol-PMMA Smart Biocomposite: Microcellular Foaming, Shape Morphing, and

Donghwan Lim1, Jaehoo Kim2, Tae Young Kim3

  • 1School of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea.

ACS Applied Materials & Interfaces
|December 9, 2025
PubMed
Summary

Researchers developed a smart biocomposite using Nitinol and PMMA for advanced medical devices. This material offers shape morphing, controlled drug release, and enhanced strength, paving the way for minimally invasive therapies.

Keywords:
drug releaseelectromagnetic inductionmicrocellular foaming processshape morphingsmart biocomposites

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Medical Device Technology

Background:

  • Developing smart biomaterials for in vivo applications is crucial for therapeutic medicine.
  • Existing materials often lack multifunctionality and remote actuation capabilities.
  • Advanced composites are needed to integrate complex functions for minimally invasive medical devices.

Purpose of the Study:

  • To fabricate a remotely actuated, multifunctional smart biocomposite using Nitinol and PMMA.
  • To investigate the composite's capabilities for shape morphing, microcellular foaming, and controlled drug release.
  • To evaluate the potential of the Nitinol-PMMA composite for applications like vascular clamping.

Main Methods:

  • Fabrication of a Nitinol-PMMA composite.
  • Application of a noncontact electromagnetic field to induce shape morphing and microcellular foaming.
  • In vitro testing for vascular clamping potential and cytocompatibility with NIH 3T3 fibroblasts.
  • Drug release kinetic analysis using the Korsmeyer-Peppas model.

Main Results:

  • The Nitinol-PMMA composite demonstrated simultaneous shape morphing and microcellular foaming.
  • Impact strength was enhanced by 143% due to microcellular foaming.
  • Controlled release of sodium benzoate (NaBz) was achieved, governed by a quasi-Fickian mechanism.
  • The composite showed excellent cytocompatibility and potential for vascular clamping.

Conclusions:

  • The fabricated Nitinol-PMMA biocomposite successfully integrates shape morphing, microcellular foaming, and controlled drug delivery.
  • This remotely actuated system offers a promising approach for developing advanced, minimally invasive medical devices.
  • The material's properties suggest significant potential for customized therapies and improved medical interventions.