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Botulinum Toxin as a Tool to Reduce Hyperhidrosis in Amputees
Carolina Gonzalez Bravo1, Jazmin Newton1, Nicole A Negbenebor1
1Dr. Gonzalez Bravo is from the Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City. Drs. Newton and Negbenebor are from the Department of Dermatology, University of Iowa Hospitals & Clinics, Iowa City.
Cutis
|December 9, 2025
Summary
Botulinum toxin (BTX) injections offer relief for amputees experiencing prosthetic discomfort and residual limb pain. A staged, targeted injection technique effectively managed pain and hyperhidrosis in one patient.
Area of Science:
- Medical Science
- Regenerative Medicine
- Clinical Practice
Background:
- Amputees often suffer from prosthetic discomfort and residual limb pain.
- Hyperhidrosis of the residual limb can exacerbate pain and affect prosthetic use.
Purpose of the Study:
- To describe a novel technique for administering botulinum toxin (BTX) injections for prosthetic discomfort and hyperhidrosis in amputees.
- To evaluate the efficacy of this staged, targeted BTX injection approach.
Main Methods:
- The residual limb was divided into targeted injection areas.
- Botulinum toxin was administered in stages to these targeted areas.
- Patient outcomes regarding comfort and hyperhidrosis were assessed.
Main Results:
- The staged, targeted BTX injection technique demonstrated excellent outcomes.
- The patient experienced enhanced comfort and effective management of hyperhidrosis.
- The treatment successfully addressed pain associated with prosthetic use.
Conclusions:
- A personalized, staged approach to BTX injections is effective for managing prosthetic discomfort and hyperhidrosis in amputees.
- This technique offers a viable solution for improving quality of life in amputee patients.
- Addressing individual patient needs is crucial for successful therapeutic outcomes.

